eng
Turkish Society of Thoracic Surgery
Current Thoracic Surgery
2548-0316
2017-02-28
2
1
1
4
10.26663/cts.2017.0001
11
article
Laparoscopic heller myotomy is equally efficient and safe in patients who had pre-myotomy endoscopic interventions when compared with those with no interventions
Zeynep Bilgi
1
Adamu Issaka
2
Hasan Fevzi Batırel
3
Department of Thoracic Surgery, Kars Harakani State Hospital, Kars, TurkeyDepartment of Thoracic Surgery, Tamale Teaching Hospital, Tamale, GhanaDepartment of Thoracic Surgery, Faculty of Medicine, Marmara University, Istanbul, Turkey<b> Background:</b> Endoscopic treatment (ET) methods for achalasia such as balloon dilatation and botulinum toxin injection has good success for short and medium term management of achalasia. However some patients either need repeat attempts or referred to surgery. In this study we analyzed and compared the perioperative and disease specific quality of life outcomes of achalasia patients who either underwent surgery as a first line treatment and the ones who underwent ET method prior to surgery. <p>
<b> Materials and Methods:</b> The patients who underwent standard of care diagnostic workup and surgery for achalasia by the same surgical team between 2007 and 2014 were recorded in a prospective database. The patients who underwent surgery as a first line treatment (Group 1, n = 55) and the patients who underwent prior ET (Group 2, n = 33) were identified. Demographic data, peroperative complications, length of hospital stay, pre- and postoperative Eckardt scores were recorded and analyzed. <p>
<b> Results:</b> A total of 88 patients out of 105 were available for follow up with average follow up time of 61.9 ± 35.8 months. The mean age was 43.3 ± 15.6. Mean hospital stay was 2.3 ± 0.8 days and there was no mortality. Average duration of the effectivity of ET before myotomy was 5.7 ± 7.7 months. Peroperative complications not significantly accumulated in either group. Both groups showed comparable drop in Eckardt scores. <p>
<b> Conclusions:</b> Heller myotomy and Dor fundoplication is a safe and durable option for treatment of achalasia for both treatment naive patients and patients with previous repeated ET modalities.
https://cts.tgcd.org.tr/pdf.php?id=11
AchalasiaHeller myotomybotulinum toxinsurgery
eng
Turkish Society of Thoracic Surgery
Current Thoracic Surgery
2548-0316
2017-02-28
2
1
5
10
10.26663/cts.2017.0002
12
article
Upregulated mrna expression of mtor in surgically resected early stage non-small cell lung carcinoma: a potential molecular targeted therapy
Muhammet Sayan
1
Ali Çelik
2
Şevki Mustafa Demiröz
3
Hacer İlke Önen
4
Nalan Akyürek
5
Ece Konaç
4
İsmail Cüneyt Kurul
2
Abdullah İrfan Taştepe
2
Department of Thoracic Surgery, School of Medicine, Kahramanmaras Sütçü İmam University, Kahramanmaras,Department of Thoracic Surgery, School of Medicine, Gazi University, Ankara,Department of Thoracic Surgery, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, AnkaraDepartment of Medical Biology and Genetics, School of Medicine, Gazi University, AnkaraDepartment of Pathology, School of Medicine, Gazi University, Ankara, Turkey<b> Background:</b> Non-small cell lung cancer (NSCLC) comprises about 85% of all lung cancers. Although many attempts for early detection and treatment, prognosis of NSCLC is still poor. In recent years the pathways and the genes that play role in lung cancer development were researched widely. PI3K/AKT/MTOR which is thought to be efficacious in the development of many cancer which controls the expression of many genes playing an important role in cell proliferation, metastasis, resistance to apoptosis and angiogenesis. Also the increase in CCND1 expression was shown in several cancer types. The aim of this study is to search the mRNA expression profile of AKT, MTOR and CCND1 genes which has been thought to play role in NSCLC development, and their expression in different pathological stages and histological types of the disease. <p>
<b> Materials and Methods:</b> Forty-four NSCLC patients who didn"t get neoadjuvant therapy were included in this study. The samples from tumor and matched normal lung tissue were obtained from resection specimens (lobectomy or pneumonectomy). Total cellular RNA was isolated from the samples. The mRNA expression levels of AKT1, mTOR and CCND1 genes were measured by quantitative real-time polymerase chain reaction (qPCR). <p>
<b> Results:</b> Our findings revealed a statistically significant increase of mTOR expression on mRNA levels (P < 0.05). Although AKT and CCND1 expression slightly increased in malign tissues, these changes in the expression were not significant (P > 0.05). The mRNA expression of mTOR was also upregulated and it was statistically significant for early stage disease and adenocarcinoma subtype (P < 0.05). <p>
<b> Conclusions:</b> Inhibition of mTOR gene expression at mRNA level might be potential target for future treatment strategies of NSCLC.
https://cts.tgcd.org.tr/pdf.php?id=12
non-small cell lung cancermRNA expressionAKT1mTORCCND1
eng
Turkish Society of Thoracic Surgery
Current Thoracic Surgery
2548-0316
2017-02-28
2
1
11
14
10.26663/cts.2017.0003
13
article
Diagnosis and treatment approaches of the lung hydatid cysts in childhood
Özgür Katrancıoğlu
1
Ekber Şahin
1
Şule Karadayı
1
Melih Kaptanoğlu
1
Department of Thoracic Surgery, School of Medicine, Cumhuriyet University, Sivas, Turkey<b> Background:</b> Cyst hydatid is an important health problem in childhood and adult age group. We aimed to present the management of childhood cyst hydatid cases treated with surgery. <p>
<b> Materials and Methods:</b> The records of 33 patients that were operated on for lung cyst hydatid disease at our clinic between 1999 and 2016 were evaluated retrospectively in terms of demographic data, clinical findings, location of cysts, treatment methods and follow-up. <p>
<b> Results:</b> Among 33 patients included in this clinical analysis study, 20 were male (60.6%) and the mean age was 11.5 (4-15 years). The most common complaint was cough that was observed in 16 patients (48.4%). 78.8% of the patients had only one cyst, whereas 21.2% of the patients had multiple cysts. Cystotomy was performed in 12 patients (36.4%), cystotomy + capitonage in 14 patients (42.4%), and decortication in addition to cystotomy + capitonage in 7 patients (21.2%). There were no postoperative complications and no recurrences were observed during the follow-up. <p>
<b> Conclusions:</b> Surgical treatment is the primary treatment that can be performed successfully and safely in childhood lung cysts hydatids.
https://cts.tgcd.org.tr/pdf.php?id=13
Pulmonary hydatid cystspediatric patientstreatment approachessurgery
eng
Turkish Society of Thoracic Surgery
Current Thoracic Surgery
2548-0316
2017-02-28
2
1
15
19
10.26663/cts.2017.0004
14
article
Solitary fibrous tumors, should they always considered to be benign gigantic masses?
Soner Gürsoy
1
Banu Yoldaş
1
Ahmet Üçvet
1
Ozan Usluer
1
Serkan Yazgan
1
Zekiye Aydoğdu Dinç
2
Department of Thoracic Surgery, Izmir Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, IzmirDepartment of Pathology, Izmir Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, Izmir, Turkey<b> Background:</b> Solitary fibrous tumors (SFT) are rare seen tumors assessed to be originated from pleura. Even though they are benign, after their complete resections malignant recurrences might be seen in follow up period. In this study, based on our case series undergone complete surgical resection due to SFT, we looked for an answer whether if it is convenient to accept these tumors as benign or not. <p>
<b> Materials and Methods:</b> Patients undergone surgery between January 2000 and January 2011 were included in this study. Follow up data, patients and tumor histopathological characteristics were analysed. <p>
<b> Results:</b> Our series consisted of 14 cases (eight male, six female) with a mean age of 49.5 ± 15.3 (15-70 years). All patients" undergone thoracotomy, and complete resection was performed. The mean follow-up was 50.3 ± 30.6 months (between 9 -101 months). Two recurrences were detected and both patients died due to recurrent disease. <p>
<b> Conclusions:</b> Though they are considered to be benign lesions, SFT have a potential to come along with malignant recurrences. Recurrences were observed in giant tumors and this makes us think if it is possible to overlook a malignant focus in histopathological observation in such kind of big tumors. In this sense, patients should be informed in this regard and a complete and wide resection should be performed as much as possible with a long time follow up period as malignant diseases.
https://cts.tgcd.org.tr/pdf.php?id=14
Pleuralungintrathoracic pathologywedge resection
eng
Turkish Society of Thoracic Surgery
Current Thoracic Surgery
2548-0316
2017-02-28
2
1
20
22
10.26663/cts.2017.0005
15
article
Video-assisted thoracoscopic removal of esophageal leiomyoma in a patient with aberrant right subclavian artery
Zeynep Bilgi
1
Okan Dericioğlu
2
Hakan Ömercikoğlu
3
Çağatay Çetinkaya
3
Hasan Fevzi Batırel
3
Kars Harakani State Hospital, Department of Thoracic Surgery, KarsMarmara University, Faculty of Medicine, Department of Cardiovascular Surgery, İstanbulMarmara University, Faculty of Medicine, Department of Thoracic Surgery, İstanbul, TurkeyEsophageal leiomyoma one of the most common esophageal tumors and frequently cause dysphagia,
requiring surgical removal for symptom control. Aberrant right subclavian artery may also cause
similar symptoms but its incidence is lower. We report a case who had dual pathologies as possible
causes of dysphagia. A straightforward bi-portal video-assisted thoracoscopic removal of an esophageal
leiomyoma was performed in a patient with an aberant right subclavian artery coursing posterosuperior
to the leiomyoma.
https://cts.tgcd.org.tr/pdf.php?id=15
EsophagusleiomyomaVATSaberrant right subclavian artery
eng
Turkish Society of Thoracic Surgery
Current Thoracic Surgery
2548-0316
2017-02-28
2
1
23
26
10.26663/cts.2017.0006
16
article
Isolated giant chest wall metastasis of papillary thyroid carcinoma; case report
Kemal Karapınar
1
Celalettin İbrahim Kocatürk
1
Ali Cevat Kutluk
1
Nural Ören
2
Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Department of Thoracic Surgery, IstanbulYedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Department of Pathology, Istanbul, Turkey.Pulmonary metastases of papillary thyroid carcinoma (PTC) is rare and generally present as a micronodular
or a miliary pattern. Herein we present a single giant chest wall metastasis of PTC that caused mediastinal
shift which was not reported in the literature. A 67 year old female patient admitted to the hospital due
to shortness of breath. A right sided mass on the chest wall and thyroid nodules were detected. PTC was
diagnosed and the patient underwent a total thyroidectomy. pT3N0 were evaluated postoperatively. PETCT
demonstrated the mass at right hemithorax (12 cm lesion, SUV max=7.2) plus needle biopsy showed
a metastasis of PTC. A chest wall resection plus right upper lobectomy and lymph node dissection was
performed as the first choice for PTC metastasis.
https://cts.tgcd.org.tr/pdf.php?id=16
papillary thyroid carcinomachest wallmetastasisgiantdyspnea
eng
Turkish Society of Thoracic Surgery
Current Thoracic Surgery
2548-0316
2017-02-28
2
1
27
29
10.26663/cts.2017.0007
17
article
A giant mediastinal ectopic goiter causing dyspnea and dysphagia
Ali Cevat Kutluk
1
Yunus Seyrek
1
Celalettin İbrahim Kocatürk
1
Mehmet Ali Bedirhan
1
Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Department of Thoracic Surgery, Istanbul, TurkeyPrimary mediastinal ectopic goiter (PMG) is defined as the presence of thyroid tissue in the mediastinum
without having a continuity between the cervical thyroid and the mediastinal goiter. A fifty-seven yearold
man admitted to our clinic suffering from dyspnea, chest pain, shortness of breath, and dysphagia for
almost two months. Thorax computed tomography revealed a mass of 12 cm in the posterior mediastinum,
compressing the trachea and esophagus. The mass is resected completely via a right thoracotomy.
https://cts.tgcd.org.tr/pdf.php?id=17
Ectopic goitermediastinumdyspnea
eng
Turkish Society of Thoracic Surgery
Current Thoracic Surgery
2548-0316
2017-02-28
2
1
30
35
10.26663/cts.2017.0008
18
article
Endobronchial coils – therapeutic innovations for severe emphysema
Martin Hetzel
1
Clinic of Pneumology, Internal Medicine Intensive Care, Respiratory Medicine and General Internal Medicine, Stuttgart, GermanyEmphysema is a frequent phenotypic manifestation of chronic obstructive pulmonary diseases which does not
respond to pharmacotherapy. Interventional methods can provide relief for severely ill and highly symptomatic
emphysema patients. A quite well studied endoscopic method is the minimally invasive, non-surgical
procedure with coils. Coils are small, shape-memory Nitinol implants designed to gather and compress lung
tissue, re-tension the diseased airway network and increase the elastic recoil in the emphysematous lung. To
date, the positive benefit-risk ratio of coils is documented by several well-designed randomized clinical trials.
https://cts.tgcd.org.tr/pdf.php?id=18
obstructive pulmonary diseaseemphysemavolume reductionendobronchial coils
eng
Turkish Society of Thoracic Surgery
Current Thoracic Surgery
2548-0316
2017-02-28
2
1
36
45
10.26663/cts.2017.0009
19
article
Endoscopic lung volume reduction in chronic obstructive airway disease using one-way valves
Konstantina Kontogianni
1
Ralf Eberhardt
1
Department of Pulmonology and Critical Care Medicine, Heidelberg University, Heidelberg, GermanyChronic obstructive airway disease (COPD) is a progressive, irreversible and debilitating disease causing lung hyperinflation. Apart from smoking cessation and conventional medical treatment, lung volume reduction surgery (LVRS) has been used for several years but it involves a major thoracic surgery with high incidence of postoperative complications. In the past decade, different approaches of minimally invasive endoscopic lung volume reduction (ELVR) have been developed which differ in indication, mechanism of action, reversibility and are divided into two groups: blocking and non-blocking devices. <p>
The endobronchial valves belong to the group of blocking devices available and have the largest series of treated patients. These one way valves are used to occlude the most emphysematous and hence destroyed lobe of the lung. Two different types of valves are available on the market: endobronchial valves (EBV, Zephyr valves) and intrabronchial valves (IBV, Spiration valves). They differ in shape but have a similar mechanism of action. <p>
In order to improve the outcome of the ELVR using valves, dedicated screening involving pulmonary function and exercise capacity testing as well as qualitative and quantitative CT analysis and perfusion scan are necessary. Numerous studies in the past years have shown the efficacy and complications following valve therapy. It has been demonstrated that patients with complete fissures show a more pronounced benefit and a significant target lobe volume reduction. Furthermore, unilateral implantation aiming at obtaining complete lobar occlusion has been more effective than the bilateral incomplete treatment. Regarding possible complications, apart from pneumothorax, COPD exacerbations, hemoptysis and valve migrations have been reported. <p>
Summarizing, in comparison to LVRS, ELVR using valves is a less invasive alternative with the opportunity to improve shortness of breath, exercise capacity, and quality of life in the patients, who have reached the end of their conventional treatment options.
https://cts.tgcd.org.tr/pdf.php?id=19
emphysemaendoscopic lung volume reductionvalve therapy