2Department of Thoracic Surgery, Van Yüzüncü Yıl University, Faculty of Medicine, Van, Turkey DOI : 10.26663/cts.2020.00025 Viewed : 3727 - Downloaded : 1070 Background: The aim of this study is to analyze prognostic biomarkers, and determine the biomarkers which are more sensitive in the patients that were presented with acute chronic obstructive pulmonary disease (COPD) exacerbation to the emergency department.
Materials and Methods: The data of 243 patients presented with acute COPD exacerbation and 122 COPD patients with stable status as control group were analyzed retrospectively. The patients, whose arterial blood gas (ABG) studied, with Acute COPD exacerbation were identified as Group I. The patients whose venous blood gas (VBG) studied were identified as Group II and stable COPD patients whose ABG studied were identified as Control Group. The prognostic biomarker values were compared in the patients of Group I, Group II and Control Group.
Results: The mean age of the patients was 68.61 ± 11.02 and the mean age of the control group was 68.25 ± 11.07. It was found that platelet lymphocyte ratio (PLR) values were very high in both Group I and Group II compared to the control Group (P < 0.001). There was a significant difference related with mean erythrocyte distribution width (RDW) in Group I, mean erythrocyte volume (MCV)’ in group II, MPV and platelet count (PLT) in both Group I and Group II (P < 0.001).
Conclusions: Especially in acute COPD exacerbation, PLR may be a useful inflammatory biomarker to reflect the severity and activity of inflammation in COPD patients.
Keywords : chronic obstructive pulmonary disease, biomarker, platelet-lymphocyte ratio, emergency department