2Department of Thoracic Surgery, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Türkiye DOI : 10.26663/cts.2025.026 Viewed : 10 - Downloaded : 6 Background: The aim of this study was to evaluate the prognostic impact of the Geriatric Nutritional Risk Index (GNRI) on survival in patients aged 70 years and older who underwent surgery for earlystage non-small cell lung cancer (NSCLC).
Material and Methods: The study included 234 patients with pathological stage 1-2 who underwent surgery at two centers between 2007 and 2020 and who did not receive preoperative neoadjuvant therapy. Patients were divided into two groups based on age: 70-75 years (Group 1) and ≥75 years (Group 2). GNRI was calculated based on serum albumin level and body weight. The difference in survival between the groups was evaluated using Kaplan-Meier analysis, and the prognostic value of GNRI was evaluated using ROC analysis.
Results: No significant association was found between the GNRI value and overall survival (p = 0.506). However, in the ≥75 age group, the survival predictive potential of the GNRI was found to be moderate in ROC analysis (AUC = 0.638). The GNRI cut-off value for this group was determined as 55.7. No significant association was found between the GNRI and clinical parameters such as age, gender, or tumor stage.
Conclusions: The GNRI may be a potential biomarker for predicting survival, especially in NSCLC patients aged 75 and older. Preoperative nutritional support may improve clinical outcomes in patients with low GNRI values. The GNRI may contribute to personalized treatment decisions in the evaluation of elderly NSCLC patients.
Keywords : geriatric nutritional risk index, non-small cell lung cancer, elderly patients, survival, nutritional status, prognostic biomarker