Current Thoracic Surgery 2016 , Vol 1 , Issue 1
Multimodality treatment of primary mediastinal germ cell tumor with growing teratoma syndrome: a case report
Necdet Öz1,Ahmet Bülent Kargı2,Ayşegül Kargı3,Akın Yıldız4,Saim Yılmaz5
1Department of Thoracic Surgery, Medstar Antalya Hospital, Antalya, Turkey
2Department of Thoracic Surgery, Medicalpark Antalya Hospital, Antalya, Turkey
3Department of Medical Oncology, Medstar Antalya Hospital, Antalya, Turkey
4Department of Nuclear Medicine, Medstar Antalya Hospital, Antalya, Turkey
5Department of Interventional, Medstar Antalya Hospital, Radiology Antalya, Turkey
DOI : 10.26663/cts.2016.0006 Viewed : 6513 - Downloaded : 1935 Germ cell tumors arise from errors occurring during the migration of embryonic stem cells to the gonads. They constitute 10-15% of malignant mediastinal tumors. Thirty-nine years old male patient was admitted with shortness of breath and gynecomastia. Positron emission tomography / Computed tomography (PET/CT) showed hypermetabolic mediastinal mass in the anterior mediastinum. Serum tumor markers were elevated. Mixed germ cell tumor was diagnosed via transthoracic tru-cut biopsy. After three cycles of systemic cisplatin, etoposide and bleomycin treatment, PET/CT showed a decreased metabolic activity but an increase in the size of mass. "Growing teratoma syndrome" was diagnosed. The excision of the mass was performed via a median sternotomy. Then autologous stem cell transplantation was performed. Patients was presented as a successful example of a multimodality treatment of a primary mediastinal germ cell tumor with GTS. Keywords : Germ cell tumor; mediastinal mass; growing teratoma syndrome; surgery