Materials and Methods: 20 New Zealand rabbits were used and divided into 4 groups. Pneumonectomy had performed firstly in each subject, then for 3 hours, normal and high volume of crystalloid and colloid fluids were administered. The first group were administered 3 ml/kg/h crystalloid (0.9% NaCl), the second group received 10 ml/kg/h of the same crystalloid, the third group were administered 3 ml/ kg/h colloid (6% HES/0.7) and the fourth group received 10 ml/kg/h of the same colloid infusion. Pneumonectomy and remaining lung materials were weighed when wet and dry and pathologic investigation was performed with a light microscopy.

Results: There was no significant difference between the preoperative and postoperative wet/dry ratio (W/DR) of pneumonectomy and remaining lung material in all groups administered crystalloid and colloid (1st Group Z = 0.707; p = 0.480, 2nd Group Z = 0.577; p = 0.564, 3rd Group Z = 0.577; p = 0.564, 4th Group Z = 0.677; p = 0.498). There was no significant difference identified between pneumonectomy material W/DR for all crystalloid and colloid groups (x2 = 2.787; p = 0.426) and again between the remaining lung material W/DR (x2 = 2.858; p = 0.414). The histopathologic assessments of all groups were similar.

Conclusion: Administration of crystalloid or colloid fluids at normal or high volume was assessed not be responsible alone for the PPE etiology in subjects with normal cardiac function. Histopathologic findings were similar in all groups. Keywords : pulmonary edema, pneumonectomy complications, pulmonary resection