Abstract
Introduction
Case Presentation
Chest radiography and computed tomography (CT) revealed a 7 cm heterogeneous posterior mediastinal tumor with contrast enhancement (Figures 1,2). Magnetic resonance imaging (MRI) further demonstrated an encapsulated, highly cellular tumor located in the left costovertebral groove at the level of D7, with a cystic component and intense contrast enhancement. There was no evidence of extension or invasion of the aorta.
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Figure 1: The chest X-ray showing a giant posterior mass on the left side. |
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Figure 2: Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a 7 cm heterogeneous, encapsulated, and highly cellular posterior mediastinal tumor located in the left costovertebral groove at the level of D7, with a cystic component and intense contrast enhancement. |
After a multidisciplinary discussion, the decision was made to perform laboratory analysis of catecholamine metabolites, PET scan and a preoperative embolization. Laboratory findings showed urine normetadrenaline at 269 nmol/24 h (normal range < 281 nmol/24 h), urine metadrenaline at 59 nmol/24 h (normal range < 159 nmol/24 h), and urine 3-ortho-methyldopa at 1981 nmol/24 h (normal range < 329 nmol/24 h). Positron emission tomography with fluorodeoxyglucose-computed tomography (FDG-PET/CT) revealed positive FDG uptake in the mediastinal mass lesion with areas corresponding to those enhanced on contrast CT (SUVmax: 6.03) (Figure 3). No abnormal FDG uptake was observed in other organs.
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Figure 3: PET/CT showing areas of increased FDG uptake within the tumor (SUVmax: 6.03). |
The patient underwent angiography and preoperative embolization of the 4th, 6th, and 7th intercostal arteries using coil placement to reduce blood inflow and minimize the risk of recanalization, with identification of the artery of Adamkiewicz originating from the 9th intercostal artery (Figures 4,5). The surgery was done 24 hours later.
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Figure 4: Endovascular treatment; anastomotic network perfusing the mediastinal mass (A), complete embolization of T7 after coil placement (B) (Radiology Department, Hassan II University Hospital, Fès). |
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Figure 5: Identification of the artery of Adamkiewicz originating from the 9th intercostal artery (Radiology Department, Hassan II University Hospital, Fès). |
The tumor was removed via a conservative thoracotomy approach. The mass was encapsulated and relatively easy to excise, except near the D7 paraspinal region, where dissection was more challenging (Figure 6). There were no perioperative complications, including blood loss or neurological complications. We discharged the patient on the third postoperative day.
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Figure 6: An intraoperative image showing the tumor implantation site (white arrow) (A), the excised left mediastinal-paravertebral mass (B). |
The pathological findings of the resected mass contained grossly visible neuroblastomatous nodules including ganglioneuromatous components. Immunohistochemical staining revealed tumor cells positive for chromogranin A, and synaptophysin. Ki-67 labeling index was 30% in the area. The patient underwent a thoraco-abdomino-pelvic CT scan three months after surgery, which returned normal. He is currently under close clinical follow-up (24 months) during which no recurrence or complications have been observed. Written informed consent was obtained from the patient for the use of the medical data in academic studies.
Discussion
The clinical presentation of neuroblastic tumors is highly variable, ranging from an asymptomatic mass to a primary tumor causing severe illness due to local invasion, widespread metastatic disease, or both. CT and MRI are the most commonly used imaging modalities for evaluating ganglioneuroblastoma. On CT, the appearance of these tumors ranges from well-marginated, oblong paravertebral masses with homogeneous enhancement to irregular, cystic, hemorrhagic, or locally invasive lesions [11,12]. On MRI, ganglioneuroblastoma appears hypointense or isointense on T1-weighted images, and hyperintense with a heterogeneous appearance on T2-weighted images [13]. PET/CT is an additional tool that can aid in diagnosing distant metastasis [12]. Elevated levels of serum neuron-specific enolase (NSE) and urinary catecholamine metabolites are observed in 90% of pediatric neuroblastoma (NB) cases. However, their elevation is rarely observed in adolescents, making them less reliable in this age group [14], which is the case for our patient.
In our experience, preoperative embolization is often recommended to optimize both preoperative and intraoperative conditions during extensive resective surgery. This technique minimizes blood flow to hypervascular tumors by targeting feeder vessels, which facilitates tumor shrinkage and alters its consistency. However, surgery should be performed within 24 hours of embolization. Identifying radiculomedullary arteries (RMAs), such as the artery of Adamkiewicz, is critical to prevent inadvertent embolization of spinal arteries and avoid severe complications [15,16].
Preoperative embolization of large mediastinal tumors with complex blood supplies is a well-established approach. Puma et al. reported three cases of highly vascularized giant thoracic sarcomas treated with preoperative embolization. In all cases, tumor size was reduced, and the resulting perilesional edema facilitated surgical dissection [17,18].
Biopsy can be useful for establishing a preoperative diagnosis [19] however, false-negative results may occur. Ganglioneuroblastomas can look like a neuroblastoma in a partial ganglioneuroma stroma [20].
Early and radical surgery is the best treatment available for mediastinal GNBs [21,22]. In adults, prognosis depends on surgical margin resection. According to Koike et al, adult patients with ganglioneuroblastomas that were only partially resected (R1 or R2) or left unresected had a survival period of less than 24 months [23]. In addition, tumor size at diagnosis may be associated with prognosis in adult GNB. Tumors larger than 8 cm in diameter tend to metastasize to distant organs [24].
There is no established evidence regarding the effectiveness of chemotherapy or radiotherapy in the survival of patients with GNB or neuroblastic tumor. This may be related to the fact that adults have a poorer tolerance to chemotherapy compared to that of children [25]. Further studies are required to confirm these observations.
In conclusion, patients with nodular GNB tumors represent a small subgroup characterized by significant heterogeneity in outcomes, similar to the overall neuroblastoma (NB) population. GNB should be considered a potential posterior mediastinal tumor, even in adult patients. The curative treatment is complete surgical resection; however, careful follow-up is necessary to monitor for metastasis and recurrence.
Declaration of conflicting interests
The authors declared no conflicts of interest with respect
to the authorship and/or publication of this article.
Funding
The authors received no financial support.
Author contribution
IA,HH,ML; conceptualization, IA,MT,KEA; data collection
and patient management, MM; radiological
analysis, IA; writing – original draft, HH,ML; co-writing
– review & editing:, MS,YO; supervision. All authors
contributed significantly to the drafting and revision
of the manuscript and approved the final version.
Acknowledgements
The authors wish to thank the Departments of Radiology
and Pathology at Hassan II University Hospital in
Fès for their support and collaboration in the management
of this case.
Reference
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