Materials and Methods: This retrospective observational study included 48 consecutive patients with histopathologically confirmed NSCLC who underwent uniportal minimally invasive anatomical lung resection between January 2024 and December 2025. Patients who underwent completion resection, had non-NSCLC histology, or lacked paired laboratory data were excluded. Preoperative laboratory values were compared with those obtained at the postoperative outpatient assessment between postoperative days 25 and 34. The primary endpoint was the change in hemoglobin, albumin, lymphocyte, and platelet score (HALP). Secondary endpoints were changes in neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, prognostic nutritional index, C-reactive protein-to-albumin ratio, and systemic immune-inflammation index.

Results: The cohort included 37 uniportal video-assisted thoracic surgery and 11 uniportal roboticassisted thoracic surgery patients. HALP decreased significantly, whereas platelet-to-lymphocyte ratio and C-reactive protein-to-albumin ratio increased significantly. Hemoglobin and hematocrit decreased, while platelet count and C-reactive protein increased. No significant changes were observed in neutrophil-to-lymphocyte ratio, prognostic nutritional index, systemic immune-inflammation index, white blood cell count, neutrophil count, lymphocyte count, creatinine, or albumin.

Conclusions: The standardized postoperative outpatient assessment after uniportal minimally invasive anatomical lung resection for NSCLC suggested a selective biomarker pattern that may reflect a nonuniform early postoperative recovery process after uniportal anatomical lung resection. Keywords : carcinoma, non-small cell lung, biomarkers, thoracic surgery, video-assisted, robotic surgical procedures, hemoglobin, albumin, lymphocyte, platelet score