Current Thoracic Surgery 2016 , Vol 1 , Issue 1
Effect of tumor size on survival in pN0M0 non-small cell lung cancer patients
Gökhan Kocaman1,Cabir Yüksel1,Bülent Mustafa Yenigün1,Mehmet Ali Sakallı1,Durdu Karasoy2,Murat Özkan1, Serkan Enön1,Ayten Kayı Cangır1
1Department of Thoracic Surgery, School of Medicine, Ankara University, Ankara, Turkey
2Department of Statistics, Faculty of Science, Hacettepe University, Ankara, Turkey
DOI : 10.26663/cts.2016.0003 Viewed : 3364 - Downloaded : 1750 Background: Tumor size is one of the major prognostic determinants of non-small cell lung cancer (NSCLC). In the present study, we evaluated the effect of tumor size on survival in pN0M0 NSCLC patients.

Materials and Methods: Between 1994 and 2013, 1975 NSCLC patients underwent surgery in our center. The study included 774 NSCLC patients with pathological stage N0M0, and these patients were divided into 8 groups according to tumor diameter, as follows, Group 1: 0-10 mm, Group 2: 11-20 mm, Group 3: 21-30 mm, Group 4: 31-40 mm, Group 5: 41-50 mm, Group 6: 51-60 mm, Group 7: 61-70 mm, and Group 8: > 70 mm. We aimed to evaluate the prognostic effect of tumor size on overall survival and to determine a cut-off point for tumor size.

Results: The 5 year overall survival rate for groups 1 to 8 were 85.6%, 81.3%, 68.6%, 62.2%, 55%, 54.2%, 54.3%, and 45.6%, respectively. The mean follow-up time was 43.8 months. In multivariate analysis, age, tumor size, and surgical resection type had an independent prognostic value on survival.

Conclusions: Tumor size is an independent prognostic factor for pN0M0 NSCLC patients. A tumor size of 4 cm was found to be the most suitable cut-off point for survival which may be of help in decision-making for adjuvant chemotherapy. Keywords : Non-small cell lung cancer; tumor size; survival