Current Thoracic Surgery 2020 , Vol 5 , Issue 3
Primary pulmonary carcinosarcomas: postoperative results and survival analysis
Mustafa Vedat Dogru1,Celal Bugra Sezen1,Cemal Aker1,Volkan Erdogu1,Inanc Yazıcı1,Aysun Olcmen1,Muzaffer Metin1
1Department of Thoracic Surgery, Health of Science University, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey DOI : 10.26663/cts.2020.00024 Viewed : 3163 - Downloaded : 1175 Background: In this study, we assessed the long-term results of 11 patients that we operated due to primary pulmonary carcinosarcoma in the light of literature.

Materials and Methods: We analyzed 11 patients’ data, who underwent lung resection, retrospectively between 2009-2018. The comorbidity score was calculated according to the modified Charlson Comorbidity Index (CCI).

Results: Of the 11 patients in the study, 10 (90.9%) were male, one was female (%9.1), and the median age of the subjects was 59.18 ± 8.86. Nine of the patients (81.8%) underwent lobectomy, two of them (18.1%) underwent pneumonectomy. As a cellular type, 6 of them have squamous cell carcinoma, 5 of them have adenocarcinoma. Furthermore, as a sarcomatous component, we detected 6 of the patients have spindle cell sarcoma, 3 of them have chondrosarcoma, one of them has osteosarcoma. and one patient has angiosarcoma. Nine complications occur postoperatively in 5 patients (45.9%). The fiveyear survival rate was 36.4%. Patients who received adjuvant chemotherapy, the five-year survival rate was 50%, meanwhile, patients who did not receive adjuvant chemotherapy five-year survival rate was not detected (P = 0.006). If the patients have CCI score is two and below their five-year survival rate was 44.4%, meanwhile if the patients have CCI score is two and above their five-year survival rate was not detected (P = 0.018). Recurrence or metastasis was diagnosed in 7 patients (63.6%) postoperatively. The 5-year disease-free survival rate is 12.5%.

Conclusions: Surgical resection is still the most effective treatment modality for these patients. Adjuvant therapy and comorbidity are detected most important factors that affect the survival rate. Keywords : carcinosarcoma, survival, surgery, lung